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FUT8

Gene

3 papers4 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Doctoral Start-up Foundation of Liaoning Province and 4 more
  • Animals3

Effects

3

TGF-β signalling

upin mice1

1 study

  1. FUT8 activates TGF-β signalling in mice.

    “blocking the CF modification of transforming growth factor -β type I receptor (TGF-βR I) could reduce the activation of downstream transforming growth factor -β (TGF-β) pathways”

    Animalsalveolar epithelial cells

    Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis

    AgingSep 18, 2023

More on TGF-β signalling

Cellular senescence

upin mice1

1 study

  1. FUT8 increases cellular senescence in mice.

    “inhibition of cellular senescence by deleting the FUT8 gene could attenuate pulmonary fibrosis in vivo.”

    Animalsshown by conditional deletionlung

    Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis

    AgingSep 18, 2023

More on Cellular senescence

Pulmonary fibrosis

upin mice1

1 study

  1. FUT8 increases pulmonary fibrosis in mice.

    “inhibition of cellular senescence by deleting the FUT8 gene could attenuate pulmonary fibrosis in vivo.”

    Animalsshown by conditional deletionlung

    Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis

    AgingSep 18, 2023

More on Pulmonary fibrosis

Associations

1

Insulin/IGF-1 signalling

mixedin mice1

1 study

  1. FUT8 is associated with insulin/IGF-1 signalling in mice.

    “increased FUT8 and fucosylation influence IGF-1 signaling”

    Animalsliver

    Alteration in N-glycomics during mouse aging: a role for FUT8

    Aging cellDec 1, 2011

More on Insulin/IGF-1 signalling

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