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DLL4

Gene

2 papers1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Boston Scientific Corporation and 2 more
  • Humans1
  • Animals1

Effects

1

Atherosclerotic plaque stability

downin mice1

1 study

  1. DLL4 decreases atherosclerotic plaque stability in mice.

    “macrophage-specific knockout of Delta-like ligand 4 in atherosclerotic mice leads to reduced plaque burden and improved stability”

    Animalsshown by macrophage-specific knockout

    Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling

    Nature communications12 Feb 2024

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