DEPP1

DEPP1 has no effect on glucose homeostasis in mice.

“Depp1-KO mice displayed normal metabolic responses to CR, including preserved glucose homeostasis.”

Animalscalorie restriction

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity

Endocrinology·3 Jul 2026

DEPP1 improves glucose tolerance in mice.

“Depp1-KO mice exhibited greater weight gain, hyperphagia, increased fat and lean mass, and impaired glucose tolerance compared with wild-type littermates.”

Animals16 weeks ad libitum high-fat diet feeding16 weeksmales

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity

Endocrinology·3 Jul 2026

DEPP1 decreases weight gain in mice.

“Depp1-KO mice exhibited greater weight gain, hyperphagia, increased fat and lean mass, and impaired glucose tolerance compared with wild-type littermates.”

Animals16 weeks ad libitum high-fat diet feeding16 weeksmales

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity

Endocrinology·3 Jul 2026