Dcr-1

1. Caloric restriction increases Dcr-1 in worms.

   “In C. elegans, DR and a model of methionine restriction also promote DICER expression in the intestine”

   Model organismsintestine

   Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

   Molecular metabolism·28 Aug 2019

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1. Dcr-1 extends lifespan in flies.

   “its partial downregulation enhances oxidative stress resistance, alters lipid metabolism, and extends lifespan even under dietary restriction.”

   Model organismspartial downregulation (heterozygous)fat body

   Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8-Aop-Dilp6 axis

   Proceedings of the National Academy of Sciences of the United States of America·24 Mar 2026

1. Dcr-1 increases resistance to oxidative and nutritional stress in flies.

   “The specific depletion of Dcr-1 in the Drosophila fat body leads to changes in lipid metabolism, enhanced resistance to oxidative and nutritional stress, and is associated with a significant increase in lifespan.”

   Model organismsshown by depletion in fat bodyfat body

   FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila

   Proceedings of the National Academy of Sciences of the United States of America·4 Apr 2023

1. Dcr-1 decreases stress resistance in worms.

   “intestinal overexpression of Dicer confers stress resistance.”

   Model organismsintestinal overexpressionintestine

   Role of microRNA processing in adipose tissue in stress defense and longevity

   Cell metabolism·5 Sep 2012

1. foxo inhibits Dcr-1 in flies.

   “the JNK-activated transcription factor FOXO binds to conserved DNA-binding sites in the dcr-1 promoter, directly repressing its expression in response to nutrient deprivation.”

   Model organismsin response to nutrient deprivation

   FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila

   Proceedings of the National Academy of Sciences of the United States of America·4 Apr 2023

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