cyld-1

1. cyld-1 extends lifespan in worms.

   “CYLD-1 is essential for physiological lifespan in the nematode Caenorhabditis elegans.”

   Model organisms

   CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae

   Nature communications·4 Jun 2026

2. cyld-1 is required for lifespan in worms.

   “silencing of cyld-1, the C. elegans CYLD ortholog, fully reverses the extended lifespan of low-TORC1-activity mutant worms”

   Model organismslow-TORC1-activity mutant worms

   The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

   bioRxiv : the preprint server for biology·2 Sep 2025Preprint

1. cyld-1 improves cognitive function in worms.

   “Neuronal CYLD-1 supports cholinergic neurotransmission and GABAergic synapse integrity, ensuring intact locomotory capacity, as well as learning and memory competence.”

   Model organismsneuron

   CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae

   Nature communications·4 Jun 2026

1. cyld-1 improves physical function in worms.

   “Neuronal CYLD-1 supports cholinergic neurotransmission and GABAergic synapse integrity, ensuring intact locomotory capacity, as well as learning and memory competence.”

   Model organismsneuron

   CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae

   Nature communications·4 Jun 2026

1. cyld-1 improves synaptic transmission in worms.

   “Neuronal CYLD-1 supports cholinergic neurotransmission and GABAergic synapse integrity, ensuring intact locomotory capacity, as well as learning and memory competence.”

   Model organismsneuron

   CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae

   Nature communications·4 Jun 2026

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