INTERLEUKIN-1BETA

Intervention4 findingsMeSH D053583

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab in 1 country

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more

Outcomes

4

CCND1

downin human cells1

1 study

  1. INTERLEUKIN-1BETA decreases CCND1 in human cells.

    Cellsin primary human articular chondrocytes10 ng/mLup to four days

    Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling · Cells · 8 Aug 2026

CCND1 →

CDK4

downin human cells1

1 study

  1. INTERLEUKIN-1BETA decreases CDK4 in human cells.

    Cellsin primary human articular chondrocytes10 ng/mLup to four days

    Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling · Cells · 8 Aug 2026

CDK4 →

Senescence-associated beta-galactosidase

upin human cells1

1 study

  1. INTERLEUKIN-1BETA increases senescence-associated beta-galactosidase in human cells.

    Cellsin primary human articular chondrocytes10 ng/mLup to four days

    Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling · Cells · 8 Aug 2026

Senescence-associated beta-galactosidase →

Cell proliferation

downin human cells1

1 study

  1. INTERLEUKIN-1BETA impairs cell proliferation in human cells.

    Cellsin primary human articular chondrocytes10 ng/mLup to four days

    Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling · Cells · 8 Aug 2026

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