CASP4
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
Effects
2Motor function
downin mice1
1 study
Motor function
downin mice1
CASP4 impairs motor function in mice.
“expresses human CASP4 and recapitulates the cytoplasmic mislocalization of endogenous TDP-43 and motor dysfunction in an age-dependent manner.”
AnimalsTransgenic expression of human CASP4; age-dependent phenotype
Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology
Nature communications27 May 2026
Cytoplasmic mislocalization of endogenous TDP-43
upin mice1
1 study
Cytoplasmic mislocalization of endogenous TDP-43
upin mice1
CASP4 induces cytoplasmic mislocalization of endogenous TDP-43 in mice.
“expresses human CASP4 and recapitulates the cytoplasmic mislocalization of endogenous TDP-43 and motor dysfunction in an age-dependent manner.”
AnimalsTransgenic expression of human CASP4; age-dependent phenotype
Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology
Nature communications27 May 2026
Latest
1 in 12 monthsNature Communications
Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology
Experiments in miceMechanisms