BBC3

BBC3 is required for clearance of damaged stem and progenitor cells in mice.

“Puma deletion impairs the clearance of stem and progenitor cells that have accumulated DNA damage as a consequence of critically short telomeres.”

Animalsin telomere-dysfunctional mice

Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction

Nature cell biology·4 Dec 2011

BBC3 shortens lifespan in mice.

“deletion of Puma improves stem- and progenitor-cell function, organ maintenance and lifespan of telomere-dysfunctional mice.”

Animalsin telomere-dysfunctional mice

Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction

Nature cell biology·4 Dec 2011