AgingResearch.NewsJoin free

atgl-1

Gene

3 papers2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Model organisms3

Effects

1

Lifespan

upin worms1

1 study

  1. atgl-1 improves lifespan in worms.

    “downregulation of adipose triglyceride lipase (ATGL-1) activity suppresses both the rapid depletion of stored lipids and reduced life span of AMPK mutant dauers”

    Model organismsAMPK mutant dauers

    Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

    Nature3 Dec 2008

Upstream

1

AMPK signalling

downin worms1

1 study

  1. AMPK signalling inhibits atgl-1 in worms.

    “AMPK directly phosphorylates ATGL-1.”

    Model organismsdauer arrest

    Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

    Nature3 Dec 2008

More on AMPK signalling

Latest

Related