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Ampkalpha

There are 10 papers on Ampkalpha in aging research: none in people yet, 10 in animals.

Gene

10 papers study it6 findings

NCBI GeneTaxon

See all 10 papers on Ampkalpha

At a glance

The findings reach worms or flies, none yet in people. 4 independent labs in 4 countries.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 4 independent labs in 4 countries
  • Funders: National Institutes of Health and others
  • Animals1
  • Model organisms9

Effects

4

Sleep and activity rhythms

mediatesin flies1

1 study

  1. Ampkalpha mediates sleep and activity rhythms in flies (kinase-dependent; age- and tissue-specific).

    “revealed kinase-dependent, age- and tissue-specific modulation of sleep and activity rhythms”

    Model organismskinase-dependent; age- and tissue-specific

    Dissecting metabolic regulation of behaviors and physiology during aging in Drosophila

    Biogerontology

Lifespan

is required forin flies1

1 study

  1. Ampkalpha is required for lifespan in flies (PARP1 knockdown in muscle).

    “Double knockdown of PARP1 and AMPKα, specifically in muscle, could counteract the effects of PARP1 inhibition in Drosophila.”

    Model organismsPARP1 knockdown in muscleskeletal muscle

    Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

    Proceedings of the National Academy of Sciences of the United States of America

Muscle aging progression

mediatesin flies1

1 study

  1. Ampkalpha mediates muscle aging progression in flies.

    “we induced the constitutively active AMPK specifically in the muscles and found that the activation of the AMPK-mediated pathway was sufficient for the anti-aging effect of Metformin”

    Model organismsshown by muscle-specific constitutively active AMPK; sufficient for metformin's anti-aging effectmuscle

    Metformin suppresses progression of muscle aging via activation of the AMP kinase-mediated pathways in Drosophila adults

    European review for medical and pharmacological sciences

Dmp53

upin flies1

1 study

  1. Ampkalpha activates Dmp53 in flies.

    “AMP-activated protein kinase (AMPK)-dependent Dmp53 activation”

    Model organisms

    Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression

    Cell reports

More on Dmp53

Upstream

1

PARP1

downin flies1

1 study

  1. PARP1 inhibits Ampkalpha in flies (PARylation of AMPKα at residues E155 and E195).

    “the inhibition of PARP1 increases the activity of AMP-activated protein kinase alpha (AMPKα) and mitochondrial turnover”

    Model organismsPARylation of AMPKα at residues E155 and E195skeletal muscle

    Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

    Proceedings of the National Academy of Sciences of the United States of America

More on PARP1

Associations

1

Lipid droplet number and size

mixedin flies1

1 study

  1. Ampkalpha is associated with lipid droplet number and size in flies (panneuronal overexpression).

    “panneuronal overexpression of Ampkα altered lipid droplet number and size in the brain”

    Model organismspanneuronal overexpressionbrain

    Dissecting metabolic regulation of behaviors and physiology during aging in Drosophila

    Biogerontology

More on Lipid droplet number and size

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