GlyP

1. DILP2 inhibits GlyP in S2 cells.

   “DILP2, but not DILP5, was subsequently shown to repress enzymatic GlyP activity in S2 cells.”

   Cellsin S2 cells

   Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

   Frontiers in endocrinology·May 28, 2018

More on DILP2

1. GlyP decreases tauopathy phenotypes in human cells (iPSC-derived neurons from FTD patients).

   “ameliorates the tauopathy phenotypes in flies and induced pluripotent stem cell (iPSC) derived neurons from FTD patients”

   CellsiPSC-derived neurons from FTD patients

   Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction

   Research square·Nov 8, 2023Preprint

2. GlyP decreases tauopathy phenotypes in flies (activation of GlyP in fly tauopathy model).

   “the breakdown of neuronal glycogen by activating glycogen phosphorylase (GlyP) ameliorates the tauopathy phenotypes in flies”

   Model organismsactivation of GlyP in fly tauopathy modelbrain

   Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction

   Research square·Nov 8, 2023Preprint

1. GlyP is required for lifespan in dilp2 mutants; phosphonull, enzymatically inactive GlyP.

   “longevity was repressed by expression of phosphonull GlyP that is enzymatically inactive.”

   Model organismsin dilp2 mutants; phosphonull, enzymatically inactive GlyP

   Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

   Frontiers in endocrinology·May 28, 2018

2. GlyP extends lifespan in flies (overexpression, Ser15 phosphorylation-dependent, in flies with intact insulin genes).

   “GlyP overexpression extended lifespan in a Ser15 phosphorylation-dependent manner.”

   Model organismsoverexpression, Ser15 phosphorylation-dependent, in flies with intact insulin genes

   Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

   Frontiers in endocrinology·May 28, 2018

1. GlyP mediates neuroprotection (neuroprotection benefit of dietary restriction, via cAMP-PKA activation).

   “Our findings uncover a critical role for increased GlyP activity in mediating the neuroprotection benefit of dietary restriction (DR) through the cAMP-mediated protein kinase A (PKA) activation.”

   Model organismsneuroprotection benefit of dietary restriction, via cAMP-PKA activation

   Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction

   Research square·Nov 8, 2023Preprint