There is 1 paper on Dmp53 in aging research: none in people yet, 1 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Agencia Nacional de Promoción Científica y Tecnológica and 4 more
- Model organisms1
Effects
3autophagy induction
is required forin flies1
1 study
autophagy induction
is required forin flies1
Dmp53 is required for autophagy induction in flies (systemic autophagy induction under starvation).
“impaired autophagy induction at a systemic level, thereby reducing nutrient stress survival”
Model organismssystemic autophagy induction under starvation
Cell reports
upd2
downin flies1
1 study
upd2
downin flies1
Dmp53 decreases upd2 in flies under nutrient deprivation and high-sugar diet.
“Under both nutrient deprivation and high-sugar diet, Dmp53 activation in the fat body represses expression of the Drosophila Leptin analog, Unpaired-2 (Upd2)”
Model organismsunder nutrient deprivation and high-sugar dietfat body
Cell reports
Nutrient stress survival
upin flies1
1 study
Nutrient stress survival
upin flies1
Dmp53 increases nutrient stress survival in flies under nutrient stress.
“AMP-activated protein kinase (AMPK)-dependent Dmp53 activation is critical for sensing nutrient stress, maintaining metabolic homeostasis, and extending organismal survival”
Model organismsunder nutrient stress
Cell reports
Upstream
1Ampkalpha
upin flies1
1 study
Ampkalpha
upin flies1
Ampkalpha activates Dmp53 in flies.
“AMP-activated protein kinase (AMPK)-dependent Dmp53 activation”
Model organisms
Cell reports