ABI3BP

1. ABI3BP increases cellular senescence in human cells.

   “Its knockdown mitigated IL-1β-induced ECM degradation and reduced the level of senescence-associated markers”

   CellssiRNA knockdown in IL-1β-treated chondrocytes

   Integrated analysis of the transcriptome and proteome reveals that ABI3BP is involved in the pathogenesis of osteoarthritis

   Journal of proteomics·11 Nov 2025

More on Cellular senescence

1. ABI3BP increases extracellular matrix remodelling in human cells.

   “Its knockdown mitigated IL-1β-induced ECM degradation and reduced the level of senescence-associated markers”

   CellssiRNA knockdown in IL-1β-treated chondrocytes

   Integrated analysis of the transcriptome and proteome reveals that ABI3BP is involved in the pathogenesis of osteoarthritis

   Journal of proteomics·11 Nov 2025

More on Extracellular matrix remodelling

1. ABI3BP increases blood pressure in mice.

   “effectively suppressed Ang II-induced elevation of blood pressure.”

   Animalsshown by knockout in Ang II-treated mice

   ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway

   Mechanisms of ageing and development·30 Aug 2025

1. ABI3BP increases vascular aging in mice.

   “ABI3BP knockout ameliorated Ang II-induced vascular aging in mice”

   Animalsshown by knockout in Ang II-treated mice

   ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway

   Mechanisms of ageing and development·30 Aug 2025

1. Osteoarthritis is associated with ABI3BP in humans.

   “ABI3BP was notably elevated in OA cartilage.”

   Humanscartilage

   Integrated analysis of the transcriptome and proteome reveals that ABI3BP is involved in the pathogenesis of osteoarthritis

   Journal of proteomics·11 Nov 2025

More on Osteoarthritis