Ulcerative dermatitis

1. UCP2 protects against ulcerative dermatitis in mice.

   “earlier emergence of spontaneous ulcerative dermatitis”

   Animalsshown by knockout

   Uncoupling protein 2 protects mice from aging

   Mitochondrion·27 Jun 2016

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1. Caloric restriction lowers the risk of ulcerative dermatitis in mice (33% vs 89% ad libitum).

   “only 33% developed such lesions”

   AnimalsDMBA/TPA-treated wild-type mice60% of ad libitum intake

   Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice

   The Journal of investigative dermatology·1 Aug 1998

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1. KITL is associated with ulcerative dermatitis in mice (56% versus 20%; average onset age 441 +/- 21 versus 722 +/- 50 days).

   “Severe ulcerative dermatitis occurred in 56% of Sl/Sld mice at an average age o4f 441 +/- 21 days and in 20% of heterozygotes and homozygous normal controls”

   AnimalsSl/Sld mutant genotype versus heterozygotes and homozygous normal controls

   Effects of mutant steel alleles on leukemogenesis and life-span in the mouse

   Journal of the National Cancer Institute·1 Jan 1977

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