Intermittent methionine restriction

Intervention

2 papers6 findings

  • 2 independent labs in 1 country
  • Funder: National Institute of Diabetes and Digestive and Kidney Diseases
  • Animals2

Outcomes

6

Dermatitis

downin mice1

1 study
  1. Intermittent methionine restriction protects against dermatitis in mice.

    “high-fat diet-fed mice undergoing both interventions not only have relatively low levels of inflammation, but are also protected against the development of dermatitis.”

    Animalshigh-fat diet

    Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis

    Journal of inflammation (London, England)19 Jun 2025

More on Dermatitis

Inflammation

downin mice1

1 study
  1. Intermittent methionine restriction decreases inflammation in mice.

    “high-fat diet-fed mice undergoing both interventions not only have relatively low levels of inflammation, but are also protected against the development of dermatitis.”

    Animalshigh-fat diet

    Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis

    Journal of inflammation (London, England)19 Jun 2025

More on Inflammation

Osteoblast count

upin mice1

1 study
  1. Intermittent methionine restriction increases osteoblast count in mice.

    “increasing the number of osteoblasts.”

    Animalscompared with continuous MR

    Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction

    Aging biology23 Jan 2024

Bone strength

upin mice1

1 study
  1. Intermittent methionine restriction improves bone strength in mice.

    “the bones of intermittently methionine-restricted mice are significantly stronger than those of mice subjected to the continuous intervention.”

    Animalscompared with continuous MR

    Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction

    Aging biology23 Jan 2024

Marrow fat accumulation

downin mice1

1 study
  1. Intermittent methionine restriction decreases marrow fat accumulation in mice.

    “as well as a dramatic reduction in the accumulation of marrow fat.”

    Animalscompared with continuous MR

    Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction

    Aging biology23 Jan 2024

Bone mass

upin mice1

1 study
  1. Intermittent methionine restriction increases bone mass in mice.

    “as compared with continuous MR, IMR results in a preservation of both trabecular and cortical bone”

    Animalscompared with continuous MR

    Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction

    Aging biology23 Jan 2024

Latest