Spontaneous tumor incidence

1. Dietary nucleotides decrease spontaneous tumor incidence in rats.

   “Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes.”

   Animalslong-term feeding0.01%, 0.04%, 0.16% and 0.64% (wt/wt)

   Dietary nucleotides extend the life span in Sprague-Dawley rats

   The journal of nutrition, health & aging·Mar 1, 2013

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1. Metformin has no effect on spontaneous tumor incidence in mice.

   “treatment with metformin failed influence blood estradiol concentration and spontaneous tumor incidence in female SHR mice”

   Animalsdrinking water100 mg/kg in drinking waterfemales

   Metformin slows down aging and extends life span of female SHR mice

   Cell cycle (Georgetown, Tex.)·Sep 11, 2008

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1. Ala-glu-asp-gly decreases spontaneous tumor incidence in mice.

   “by the decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence (mainly, lung adenomas)”

   AnimalsMainly lung adenomassynthetic pineal tetrapeptide0.1 microg/animal monthly for five consecutive daysUntil natural deathfemales

   Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice

   Mechanisms of ageing and development·Jan 1, 2001

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1. Epitalon lowers the risk of spontaneous tumor incidence in mice.

   “accompanying drop in spontaneous tumour incidence”

   Animalssynthetic tetrapeptideuntil deathfemales

   Effect of pineal peptide on parameters of the biological age and life span in mice

   Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·Jan 1, 2001

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