Ala-glu-asp-gly

1. Ala-glu-asp-gly improves thymic structure recovery in chickens.

   “administered to hypophysectomized birds regardless of age promoted recovery of the morphological structures of the thymus.”

   Animalsin hypophysectomized birds regardless of agethymus

   Effect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds

   Bulletin of experimental biology and medicine·Mar 1, 2013

1. Ala-glu-asp-gly activates IFNG.

   “Thus, the immune protection of this peptide can be explained by its activation of the interferon gamma production in T-cells.”

   ReviewT-cells

   Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging

   Advances in gerontology = Uspekhi gerontologii·Jan 1, 2012

More on IFNG

1. Ala-glu-asp-gly increases lymphocyte proliferation.

   “Cell penetrating geroprotective peptide Ala-Glu-Asp-Gly has the capability to activate the proliferation of lymphocytes in thymus during its aging.”

   Reviewthymus

   Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging

   Advances in gerontology = Uspekhi gerontologii·Jan 1, 2012

1. Ala-glu-asp-gly improves thyroid hormones in chickens.

   “The normalizing effect of synthetic peptides on the concentration of thyrotrophic hormone and thyroid hormones in old hens was less pronounced than in chickens.”

   Animalsin hypophysectomized old hens

   Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens

   Bulletin of experimental biology and medicine·Feb 1, 2011

More on Thyroid hormones

1. Ala-glu-asp-gly decreases structural changes in the thyroid gland in chickens.

   “Administration of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthesized on the basis the amino acid composition of extracts from the anterior and posterior lobes of the pituitary gland, respectively, to hypophysectomized birds for 40 days significantly reduced the degree of these changes.”

   Animalsin hypophysectomized birds40 days

   Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens

   Bulletin of experimental biology and medicine·Feb 1, 2011

1. Ala-glu-asp-gly increases TSH in chickens.

   “increasing the levels of the thyroid-stimulating hormone (TSH) as well as T3 and T4”

   Animalsin hypophysectomized mature and old birds

   Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds

   Advances in gerontology = Uspekhi gerontologii·Jan 1, 2011

More on TSH

1. Ala-glu-asp-gly prevents secondary hypothyrosis in chickens.

   “significantly prevented these impairments”

   Animalsin hypophysectomized mature and old birds

   Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds

   Advances in gerontology = Uspekhi gerontologii·Jan 1, 2011

More on Secondary hypothyrosis

1. Ala-glu-asp-gly decreases spontaneous tumor incidence in mice.

   “by the decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence (mainly, lung adenomas)”

   AnimalsMainly lung adenomassynthetic pineal tetrapeptide0.1 microg/animal monthly for five consecutive daysUntil natural deathfemales

   Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice

   Mechanisms of ageing and development·Jan 1, 2001

More on Spontaneous tumor incidence

1. Ala-glu-asp-gly decreases free radical processes in mice.

   “by the decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence”

   Animalssynthetic pineal tetrapeptide0.1 microg/animal monthly for five consecutive daysUntil natural deathfemales

   Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice

   Mechanisms of ageing and development·Jan 1, 2001

1. Ala-glu-asp-gly improves estrus function in mice.

   “by slow down of the ageing of estrus function”

   Animalssynthetic pineal tetrapeptide0.1 microg/animal monthly for five consecutive daysUntil natural deathfemales

   Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice

   Mechanisms of ageing and development·Jan 1, 2001