Dietary nucleotides
Dietary nucleotides has been studied in 2 papers since 2013: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Mar 24, 2022: “An Overlooked Prebiotic: Beneficial Effect of Dietary Nucleotide Supplementation on Gut Microbiota and Metabolites in Senescence-Accelerated Mouse Prone-8 Mice”.
2 papers study it7 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Animals2
What did studies of Dietary nucleotides find?
7Studies of Dietary nucleotides measured 7 outcomes; the most studied are lactobacillus casei growth (1 study), harmful gut bacteria abundance (1) and beneficial gut microbiota abundance (1).
Lactobacillus casei growth
upin L. casei cells1
1 study
Lactobacillus casei growth
upin L. casei cells1
Dietary nucleotides increase lactobacillus casei growth in L. casei cells.
“In vitro experiments showed that NTs significantly promoted the growth, secretion of biofilm and extracellular polymeric substance of L. casei.”
Cellsin vitro
Frontiers in nutrition
Harmful gut bacteria abundance
downin mice1
1 study
Harmful gut bacteria abundance
downin mice1
Dietary nucleotides decrease harmful gut bacteria abundance in mice.
“reduced the abundance of bacteria with negative effects on the body (such as Verrucomicrobia, Ruminococcaceae, Akkermansia and Helicobacter)”
Animalsin dietfeces
Frontiers in nutrition
Beneficial gut microbiota abundance
upin mice1
1 study
Beneficial gut microbiota abundance
upin mice1
Dietary nucleotides increase beneficial gut microbiota abundance in mice.
“increased the abundance of the microbiota, which had beneficial effects on the mice (such as Lactobacillus, Candidatus saccharimonas and Lachnospiraceae_NK4A136_group)”
Animalsin dietfeces
Frontiers in nutrition
Gut microbiota diversity
upin mice1
1 study
Gut microbiota diversity
upin mice1
Dietary nucleotides increase gut microbiota diversity in mice.
“Supplementation with exogenous NTs to the diet enhanced the diversity of the gut microbiota”
Animalsin dietfeces
Frontiers in nutrition
Oxidative stress and ROS signaling
downin rats1
1 study
Oxidative stress and ROS signaling
downin rats1
Dietary nucleotides decrease oxidative stress and ROS signaling in rats.
“it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes”
Animalsdose-dependently
Dietary nucleotides extend the life span in Sprague-Dawley rats
The journal of nutrition, health & aging
Spontaneous tumor incidence
downin rats1
1 study
Spontaneous tumor incidence
downin rats1
Dietary nucleotides decrease spontaneous tumor incidence in rats.
“Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes.”
Animalslong-term feeding0.01%, 0.04%, 0.16% and 0.64% (wt/wt)
Dietary nucleotides extend the life span in Sprague-Dawley rats
The journal of nutrition, health & aging
Lifespan
upin rats1
1 study
Lifespan
upin rats1
Dietary nucleotides extend lifespan in rats.
“NTs notably increased the mean life span, and the maximal life span.”
Animalsfrom the age of 4 weeks until natural death0.01%, 0.04%, 0.16% and 0.64% (wt/wt)
Dietary nucleotides extend the life span in Sprague-Dawley rats
The journal of nutrition, health & aging