Spinocerebellar ataxia type 2

There are 5 papers on spinocerebellar ataxia type 2 in aging research: 1 observational study in people, 3 in animals, 1 in cells.

5 papers study it4 more mention it1 finding

Humans1
Animals2
Model organisms1
Cells1

Associations

1

ATXN2

upin humans1

1 study

ATXN2 raises the risk of spinocerebellar ataxia type 2 in humans (polyglutamine expansion).
“ATXN2 polyglutamine expansion drives neurodegeneration causing spinocerebellar ataxia type 2 and promoting amyotrophic lateral sclerosis”
Reviewpolyglutamine expansion
Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats
Communications biologyNov 5, 2018

Trial sponsors

Assistance Publique - Hôpitaux de Paris
1 trialPhase 342 people

Latest

2 papers in 12 months

CellsApr 27

Astro-Versus Microglia-Enriched Transcriptomes from Aged Atxn2-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies

Experiments in miceMechanisms

Cell ReportsDec 21

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias

Study in peopleMechanisms

Annals of NeurologySep 25

Staufen Impairs Autophagy in Neurodegeneration

Experiments in miceAutophagy

eLifeFeb 16

Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias

Experiments in fliesEndurance exercise

Communications BiologyNov 13

Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats

Experiments in cellsTransposable element activity

International Journal of Molecular SciencesOct 15

Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2

Experiments in animalsMechanisms

Movement DisordersApr 8

Neurorehabilitation Improves the Motor Features in Prodromal SCA2: A Randomized, Controlled Trial

Trial in peopleInterventions

Movement DisordersAug 22

Neurorehabilitation therapy in spinocerebellar ataxia type 2: A 24-week, rater-blinded, randomized, controlled trial

Trial in peopleInterventions

CerebellumJun 8

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

Experiments in animalsMechanisms