CLEC7A
In one study of 5xFAD mice, CLEC7A impairs spatial learning and memory retention and increases freezing behaviour; plaque changes differ by region, with fewer dense plaques in the subiculum and a higher diffuse/dense ratio in the dentate gyrus hilus. All five findings come from one lab and name NIH and Ono Pharmaceutical as funders.
- 1 lab in 1 country
- Funders: National Institute of Allergy and Infectious Diseases and 6 more
- Animals1
Effects
5Freezing behavior
upin mice1
1 study
Freezing behavior
upin mice1
CLEC7A increases freezing behavior in mice.
Animals5xFAD model
Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan
Frontiers in immunology3 Sep 2026
Diffuse/dense Aβ plaque ratio
upin mice1
1 study
Diffuse/dense Aβ plaque ratio
upin mice1
CLEC7A increases diffuse/dense Aβ plaque ratio in mice.
Animals5xFAD modelhilus of the dentate gyrus
Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan
Frontiers in immunology3 Sep 2026
Memory retention
downin mice1
1 study
Memory retention
downin mice1
CLEC7A impairs memory retention in mice.
Animals5xFAD model
Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan
Frontiers in immunology3 Sep 2026
Spatial learning
downin mice1
1 study
Spatial learning
downin mice1
CLEC7A impairs spatial learning in mice.
Animals5xFAD model
Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan
Frontiers in immunology3 Sep 2026
Dense Aβ plaques
downin mice1
1 study
Dense Aβ plaques
downin mice1
CLEC7A decreases dense Aβ plaques in mice.
Animals5xFAD modelsubiculum
Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan
Frontiers in immunology3 Sep 2026