CLEC7A

In one study of 5xFAD mice, CLEC7A impairs spatial learning and memory retention and increases freezing behaviour; plaque changes differ by region, with fewer dense plaques in the subiculum and a higher diffuse/dense ratio in the dentate gyrus hilus. All five findings come from one lab and name NIH and Ono Pharmaceutical as funders.

  • 1 lab in 1 country
  • Funders: National Institute of Allergy and Infectious Diseases and 6 more
  • Animals1

Effects

5

Freezing behavior

upin mice1

1 study
  1. CLEC7A increases freezing behavior in mice.

    Animals5xFAD model

    Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan

    Frontiers in immunology3 Sep 2026

Diffuse/dense Aβ plaque ratio

upin mice1

1 study
  1. CLEC7A increases diffuse/dense Aβ plaque ratio in mice.

    Animals5xFAD modelhilus of the dentate gyrus

    Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan

    Frontiers in immunology3 Sep 2026

More on Diffuse/dense Aβ plaque ratio

Memory retention

downin mice1

1 study
  1. CLEC7A impairs memory retention in mice.

    Animals5xFAD model

    Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan

    Frontiers in immunology3 Sep 2026

Spatial learning

downin mice1

1 study
  1. CLEC7A impairs spatial learning in mice.

    Animals5xFAD model

    Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan

    Frontiers in immunology3 Sep 2026

Dense Aβ plaques

downin mice1

1 study
  1. CLEC7A decreases dense Aβ plaques in mice.

    Animals5xFAD modelsubiculum

    Microglial dectin-1/Clec7a in an alzheimer's disease model: a double-edged sword across the lifespan

    Frontiers in immunology3 Sep 2026

More on Dense Aβ plaques

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