Sickle cell trait

1. Sickle cell trait was not clearly linked with incident ischemic stroke in humans (HR 1.06, 95% CI 0.89-1.25; p = 0.53).

   “After multivariable adjustment, SCT was not significantly associated with incident ischemic stroke”

   HumansHeterozygous HbAS versus homozygous reference HbAA, after adjustment for genetic ancestry and vascular risk factorsMean follow-up, 12.25 yearsn = 275,530

   Sickle cell trait showed no clear link to stroke in adults

   Neurology. Genetics·Nov 4, 2026

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1. Sickle cell trait is associated with DNA methylation in humans (103 CpGs and 119 DMRs).

   “We identified 103 differentially methylated CpGs and 119 differentially methylated regions associated with SCT.”

   Humanswhole blood

   Methylation profile of individuals with sickle cell trait

   Epigenetics·Aug 4, 2025

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1. Sickle cell trait is associated with biological age in more recent epigenetic clocks.

   “recent epigenetic clocks that incorporate clinical phenotypes or laboratory biomarkers related to adverse health outcomes are associated with accelerated aging among individuals with SCT”

   Humansin more recent epigenetic clockswhole blood

   Methylation profile of individuals with sickle cell trait

   Epigenetics·Aug 4, 2025

1. Sickle cell trait is associated with cellular senescence in SCT-positive vs SCT-negative Black adults.

   “SCT was significantly associated with lower proportions of CD8+ and CD4+ T cell subsets that include senescent-like markers”

   Humansin SCT-positive vs SCT-negative Black adults

   Alterations of T Cell Subsets Associated with Sickle Cell Trait

   Blood and genomics discovery·Oct 8, 2024

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