Neurology Genetics
Sickle cell trait showed no clear link to stroke in adults
After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.
Cohort · 275,530 peopleSickle cell disease
Who was studied275,530 adults without previous stroke or transient ischemic attack, mean 12.25 years
What changedStroke risk did not clearly differ with versus without sickle cell trait after adjustment (hazard ratio 1.06)
The catchEstimates depended on how strokes and risk factors were recorded in electronic health records