Primary Sjögren's disease

1. Primary Sjögren's disease raises the risk of dementia in humans (aHR 1.43, 95% CI 1.21 to 1.70).

   Humanspropensity score-matched

   Risk of cognitive disorders in patients with primary Sjögren's disease: data from Korean Health Insurance Service · RMD open · 24 Sep 2026

Dementia →

1. Primary Sjögren's disease raises the risk of secondary dementia in humans (aHR 2.24, 95% CI 1.45 to 3.48).

   Humanspropensity score-matched

   Risk of cognitive disorders in patients with primary Sjögren's disease: data from Korean Health Insurance Service · RMD open · 24 Sep 2026

Secondary dementia →

1. Primary Sjögren's disease raises the risk of mild cognitive impairment in humans (aHR 1.62, 95% CI 1.41 to 1.85).

   Humanspropensity score-matched

   Risk of cognitive disorders in patients with primary Sjögren's disease: data from Korean Health Insurance Service · RMD open · 24 Sep 2026

Mild cognitive impairment →

1. Primary Sjögren's disease raises the risk of Alzheimer's disease in humans (aHR 1.48, 95% CI 1.35 to 1.63).

   Humanspropensity score-matched

   Risk of cognitive disorders in patients with primary Sjögren's disease: data from Korean Health Insurance Service · RMD open · 24 Sep 2026

Alzheimer's disease →

1. Primary Sjögren's disease raises the risk of cognitive disorders in humans (aHR 1.48, 95% CI 1.36 to 1.63).

   Humanspropensity score-matched

   Risk of cognitive disorders in patients with primary Sjögren's disease: data from Korean Health Insurance Service · RMD open · 24 Sep 2026

Cognitive disorders →