Primary biliary cirrhosis

1. Primary biliary cirrhosis increases CX3CL1 in humans.

   “The expression of CCL2 and CX3CL1 was significantly higher in BECs in inflamed and damaged small bile ducts in PBC, when compared with non-inflamed bile ducts and control livers (p<0.01).”

   Humansprimary biliary cirrhosislivern = 37

   Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

   Journal of hepatology·5 May 2010

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1. Primary biliary cirrhosis increases CCL2 in humans.

   “The expression of CCL2 and CX3CL1 was significantly higher in BECs in inflamed and damaged small bile ducts in PBC, when compared with non-inflamed bile ducts and control livers (p<0.01).”

   Humansprimary biliary cirrhosislivern = 37

   Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

   Journal of hepatology·5 May 2010

More on CCL2

1. Primary biliary cirrhosis is associated with loss of chromosome Y in humans.

   “We demonstrate that Y chromosome loss indeed is higher in PBC males compared to healthy controls, and this phenomenon increases with aging.”

   Humansmales

   Y chromosome loss in male patients with primary biliary cirrhosis

   Journal of autoimmunity·1 Feb 2013

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1. Primary biliary cirrhosis is associated with γH2AX DNA-damage foci in humans.

   “gammaH2AX-DNA-damage-foci were detected in biliary epithelial cells in damaged small bile ducts and bile ductules in PBC”

   HumansDamaged small bile ducts and bile ductules; foci absent in chronic viral hepatitis and normal liversbiliary epithelial cells

   Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

   Hepatology (Baltimore, Md.)·1 Jul 2008

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1. Primary biliary cirrhosis is associated with telomere length in humans.

   “The study showed a significant decrease in telomere length in biliary epithelial cells in the damaged small bile ducts and bile ductules in PBC”

   HumansDamaged small bile ducts and bile ductules in primary biliary cirrhosis compared with normal-looking ducts, chronic viral hepatitis, and normal liversbiliary epithelial cells

   Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

   Hepatology (Baltimore, Md.)·1 Jul 2008

More on Telomere length