γH2AX DNA-damage foci

1. Primary biliary cirrhosis is associated with γH2AX DNA-damage foci in humans.

   “gammaH2AX-DNA-damage-foci were detected in biliary epithelial cells in damaged small bile ducts and bile ductules in PBC”

   HumansDamaged small bile ducts and bile ductules; foci absent in chronic viral hepatitis and normal liversbiliary epithelial cells

   Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

   Hepatology (Baltimore, Md.)·1 Jul 2008

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