Osteoarthritis risk

Disease

1 paper4 findings

Humans1

Upstream

Frailty

mediatesin humans1

1 study

Frailty mediates osteoarthritis risk in humans (mediation proportions 8,80%–21.70%).
“Frailty partially mediated the association between pain and OA (mediation proportions 8,80%–21.70%), primarily through mobility limitations such as difficulty rising from a chair.”
Humansassociation between pain and osteoarthritis
Pain changes linked to osteoarthritis risk in older adults
Research Square16 Oct 2026Preprint

Associations

Pain recovery

downin humans1

1 study

Pain recovery is associated with osteoarthritis risk in humans.
“OA risk was elevated by transitions from pain‐free to pain but reduced by recovery from pain to pain‐free status”
Humansrecovery from pain to pain-free status
Pain changes linked to osteoarthritis risk in older adults
Research Square16 Oct 2026Preprint

Pain onset

upin humans1

1 study

Pain onset is associated with osteoarthritis risk in humans.
“OA risk was elevated by transitions from pain‐free to pain”
Humanstransition from pain-free status to pain
Pain changes linked to osteoarthritis risk in older adults
Research Square16 Oct 2026Preprint

Pain

upin humans1

1 study

Pain is associated with osteoarthritis risk in humans.
“Regardless of severity, baseline pain significantly increased the risk of OA”
Humansbaseline pain, regardless of severity
Pain changes linked to osteoarthritis risk in older adults
Research Square16 Oct 2026Preprint

Latest

11 in 12 months

Research Square54 min

Pain changes linked to osteoarthritis risk in older adults

An observational analysis of 67,374 adults aged 50 or older across five cohorts linked developing or recovering from pain to later osteoarthritis risk.An observational analysis of 67,374 adults aged 50 or older across five cohorts linked developing or recovering from pain to later osteoarthritis risk.

Preprint: cohort study of 67,374 adults aged ≥ 50 years without osteoarthritisPain

Limit: Self-reported diagnoses or medication use could misclassify incident osteoarthritis

Paper

Medicine28 Sep

Higher CTI is linked to osteoarthritis risk in prediabetes

Prediabetic adults in the highest CTI quartile had an increased osteoarthritis risk (hazard ratio 1.376) over nine years of follow-up.Prediabetic adults in the highest CTI quartile had an increased osteoarthritis risk (hazard ratio 1.376) over nine years of follow-up.

Cohort study of 3,043 peopleOsteoarthritis

Paper

International Journal of Molecular Sciences28 Sep