Myocardial dysfunction

1 paper1 finding

Interventions

1

Senotherapeutics

downin reviews1

1 study

Senotherapeutics decrease myocardial dysfunction.
“Targeting of senescent cells using senotherapeutics alleviates the detrimental features of cardiac aging, including myocardial dysfunction, hypertrophy and fibrosis, and activates endogenous cardiac regeneration.”
Reviewcardiac agingheart
Targets of senescence in cardiac muscle: insights for regenerative treatments in the aged heart
Expert opinion on therapeutic targets7 May 2026

More on Senotherapeutics

Trial sponsors

Cedars-Sinai Medical Center
1 trialPhase 22 people

Funding

2 grants since 2019

Department of the ArmyUS$329kAmerican Heart AssociationUS$9.9k

Latest

10 in 12 months

Frontiers in Physiology8 Sep

Does exercise modulate ferroptosis-related cardiovascular injury? Mechanistic evidence and translational boundaries

Brain Research Bulletin22 Aug

Left ventricular myocardial strain impairment correlates with cerebral small vessel disease burden in patients with normal ejection fraction

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Cureus4 Aug

Effectiveness of Structured Exercise Programs in Patients With Conduction System Pacing and Cardiac Resynchronization Therapy: A Systematic Review

Systematic review of studies in peopleExercise

Therapeutic Advances in Drug Safety19 May

Metabolic and nutritional stress-associated dilated cardiomyopathy in the setting of semaglutide use and long-term nicotine replacement therapy: a case report and literature review

Expert Opinion on Therapeutic Targets7 May

Targets of senescence in cardiac muscle: insights for regenerative treatments in the aged heart

ReviewInterventions

Current Heart Failure Reports21 Apr

IGFBP7 and Heart Failure: From Senescence Biomarker to Therapeutic Target

ReviewMechanisms

European Heart Journal6 Mar

Senescence-related myocardial dysfunction: keeping a young heart

ReviewMechanisms

Clinical and Translational Medicine26 Feb

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis

Experiments in miceMitophagy

Cardiovascular Research23 Jan

Integrative transcriptomic profiling links telomere dysfunction to cGAS-STING activation in heart failure signatures in mice and humans

Experiments in micecGAS–STING signalling

AHA Scientific Sessions 2025 Abstract3 Nov

Nicotinamide Riboside is Protective in a Mouse Model of Heart Failure with Reduced Ejection Fraction

Experiments in miceNicotinamide riboside