Myocardial fibrosis
Disease3 papers2 findings
- Animals2
Interventions
1Astragaloside iv
downin mice1
1 study
Astragaloside iv
downin mice1
Astragaloside iv decreases myocardial fibrosis in mice.
Animalsaging-inducedheart
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 28 Sep 2026
Associations
1Mosaic loss of the Y chromosome
upin humans1
1 study
Mosaic loss of the Y chromosome
upin humans1
Mosaic loss of the Y chromosome raises the risk of myocardial fibrosis in humans.
Reviewmales
Mosaic Loss of the Y Chromosome: Mechanisms and Diseases · Protein & cell · 1 Oct 2026
Latest
4Mosaic Loss of the Y Chromosome: Mechanisms and Diseases
Killifish exhibit distinct structural changes and fibrosis during cardiac aging
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
Histology and histopathology · Hishida R et al.
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.
Toxicology and applied pharmacology · Wang H et al.
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.