Metastatic melanoma
1 paper1 finding
- Animals1
Interventions
1Anti-bcl-xl senolytic
downin mice1
1 study
Anti-bcl-xl senolytic
downin mice1
Anti-bcl-xl senolytic decreases metastatic melanoma in mice.
“A sequential strategy using cortactin depletion followed by an anti-Bcl-xL senolytic eliminated the persistent CTCs and suppressed blood-borne metastasis.”
Animalscortactin depletion followed by an anti-Bcl-xL senolytic
Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells
Cancer research19 Dec 2025
Trial sponsors
Company1 trialPhase 3134 people
Company1 trialPhase 2225 people
Company1 trialPhase 214 people
Company1 trialPhase 1/248 people
Company1 trialPhase 1/222 people
Company1 trialPhase 156 people
Dermatologic Cooperative Oncology Group
1 trialPhase 4200 people
The Netherlands Cancer Institute
1 trialPhase 3168 people
Latest
1 in 12 monthsCancer Research
Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells
Experiments in miceInterventions
Stem Cell Research & Therapy
MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
Experiments in cellsMechanisms