Genital tract infection

Disease1 paper1 finding

  • Humans1

Associations

1

SGLT2 inhibitors

upin humans1HR 1.31Low certainty

1 study

  1. SGLT2 inhibitors raise the risk of genital tract infection in humans (HR 1.31, 95% CI 1.09-1.58).

    Humanscompared with DPP-4i initiation in patients with T2DM and CKD

    SGLT2 inhibitors raise genital but not urinary infection risk · Clinical pharmacology and therapeutics · 28 Sep 2026

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Clinical Pharmacology and TherapeuticsHumans

SGLT2 inhibitors raise genital but not urinary infection risk

In patients with diabetes and kidney disease, SGLT2 inhibitors carried an infection hazard ratio of 0.99 for UTIs and 1.31 for genital infections…In patients with diabetes and kidney disease, SGLT2 inhibitors carried an infection hazard ratio of 0.99 for UTIs and 1.31 for genital infections versus DPP-4 inhibitors.

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