4 papers8 findings
Sulforaphane
downin rats1
Sulforaphane protects against dysbiosis in rats.
“and prevented some of the gut microbial changes induced by the HD.”
Animalsin chronic obesity model0.5 mg/kg, 5 days/week2 monthsfemales
Experimental neurology10 Jun 2025
Prebiotics
downin humans1
Prebiotics decrease dysbiosis in humans.
“Furthermore, prebiotics and probiotics are discussed as effective alternatives for mitigating indirect causes of gut dysbiosis.”
Review
Neuroscience10 Mar 2025
Probiotics
downin humans1
Probiotics decrease dysbiosis in humans.
“Furthermore, prebiotics and probiotics are discussed as effective alternatives for mitigating indirect causes of gut dysbiosis.”
Review
Neuroscience10 Mar 2025
Epigallocatechin gallate
downin mice1
Epigallocatechin gallate decreases dysbiosis in mice.
“EGCG also suppressed the abundance of pathogenic bacteria and preserved microbial diversity.”
Animalsaging
The Journal of nutritional biochemistry23 May 2022
Amyloid clearance
downin reviews1
Dysbiosis decreases amyloid clearance.
“However, age-associated dysbiosis disrupts glial homeostasis, amplifies neuroinflammation, and impairs amyloid clearance, thereby worsening neurodegeneration.”
Reviewage-associated dysbiosisbrain
GeroScience12 Jan 2026
Inflammation
upin reviews1
Dysbiosis increases inflammation.
“However, age-associated dysbiosis disrupts glial homeostasis, amplifies neuroinflammation, and impairs amyloid clearance, thereby worsening neurodegeneration.”
Reviewage-associated dysbiosisbrain
GeroScience12 Jan 2026
Sleep fragmentation
upin flies1
Dysbiosis induces sleep fragmentation in flies.
“dysbiosis induces sleep fragmentation through the activation of insulin-producing cells in the brain”
Model organismsvia DAP-type peptidoglycan binding to PGRP-LE
A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan
Neuron14 Aug 2023
NAD+ deficiency
upin reviews1
NAD+ deficiency is associated with dysbiosis.
“Indeed, its deficiency has been associated with enhanced gut inflammation and leakage, and dysbiosis.”
Reviewintestine
NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota
Nutrients30 Jun 2023
National Cheng-Kung University Hospital
1 trialPhase 4312 people
1 trialPhase 440 people
National Institute of Allergy and Infectious Diseases
1 trialPhase 1/210 people
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
1 trial60 people
Japan Society for the Promotion of ScienceJP¥28mHealth and Medical Research FundHK$1.2mAlzheimer's Association
Japan Society for the Promotion of ScienceMie UniversityJP¥4.6m2025–2028
Japan Society for the Promotion of ScienceKyushu UniversityJP¥17m2024–2025
Health and Medical Research FundChinese University of Hong KongHK$1.2m2023
New definition of oral dysbiosis by using the more advanced generation long sequence
Japan Society for the Promotion of ScienceKyushu UniversityJP¥6.4m2020–2023
Elderly microbiome dysbiosis, Alzheimer’s disease, and cognitive decline
Alzheimer's AssociationUniversity of Massachusetts Chan Medical School2019
After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.After six hours at 1.0 parts per million, mice had temporary breathing problems and lung tissue damage that remained seven days after exposure.
Limit: Assessment at 7 days leaves longer-term lung damage uncertain
Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.
Limit: Metformin doses were not reported, preventing assessment of the exposure required for bone protection