Down syndrome with Alzheimer's disease neuropathology

1. Down syndrome with Alzheimer's disease neuropathology increases string vessels in humans (U=13, p = 0.0009).

   “We also found an increased number of string vessels (U=13, p = 0.0009) and pericytes [t(18)=3, p = 0.005].”

   Humanspost-mortem occipital cortex lamina III-IVoccipital cortex

   Blood‐brain barrier integrity and vessel morphology in adults with Down syndrome and Alzheimer's neuropathology

   AAIC 2025 abstract·24 Dec 2025

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1. Down syndrome with Alzheimer's disease neuropathology increases vessel density in humans (t(18)=5.277, p <0.0001).

   “Compared to neurotypical controls, adults with DSAD displayed increased BM coverage [t(18)=2.145, p = 0.045], vessel density [t(18)=5.277, p <0.0001] and length [t(18)=3.43, p = 0.003].”

   Humanspost-mortem occipital cortex lamina III-IVoccipital cortex

   Blood‐brain barrier integrity and vessel morphology in adults with Down syndrome and Alzheimer's neuropathology

   AAIC 2025 abstract·24 Dec 2025

1. Down syndrome with Alzheimer's disease neuropathology increases fibrin in humans (3-fold increase, p = 0.0002).

   “we found abundant fibrin deposition in DSAD brains compared to controls (3‐fold increase, Fisher's exact test, two‐tailed, p = 0.0002)”

   Humanspost-mortem occipital cortexoccipital cortex

   Blood‐brain barrier integrity and vessel morphology in adults with Down syndrome and Alzheimer's neuropathology

   AAIC 2025 abstract·24 Dec 2025

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