P-tau epitopes

1. Down syndrome with AD neuropathology increases p-tau epitopes in humans.

   “Observed pThr181, pThr217, and pThr231 burdens were higher in DSAD compared to young DS and neurotypical controls.”

   HumansDown syndrome with AD neuropathologyfrontal cortexn = 98

   Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan

   Acta neuropathologica·22 Mar 2026

More on Down syndrome with AD neuropathology