Diabetic microvascular complications
5 papers4 findings
- Humans4
Upstream
1PhenoAgeAccel
mediatesin humans1
1 study
PhenoAgeAccel
mediatesin humans1
PhenoAgeAccel mediates diabetic microvascular complications in humans (43.0%).
“Mediation analysis revealed that PhenoAgeAccel accounted for 43.0%, 29.8%, and 33.5% of the diet association with composite DMCs, DR, and DN, respectively.”
Humansdiet association with composite DMCs
GeroScience11 Dec 2025
Associations
3Lactate
upin reviews1
1 study
Lactate
upin reviews1
Lactate raises the risk of diabetic microvascular complications.
“In DR and DKD, accumulating studies indicate that lactylation contributes to cellular dysfunction across multiple microvascular cell types”
Reviewin diabetes
Ageing research reviews12 Mar 2026
PhenoAgeAccel
downin humans1
1 study
PhenoAgeAccel
downin humans1
PhenoAgeAccel lowers the risk of diabetic microvascular complications in humans.
“Phenotypic age acceleration (PhenoAgeAccel) ≤ 0 was also linked to a reduced risk of DMCs.”
Humansin individuals with type 2 diabetes mellitus
GeroScience11 Dec 2025
Healthy diet
downin humans1HR 0.845
1 study
Healthy diet
downin humans1HR 0.845
Healthy diet lowers the risk of diabetic microvascular complications in humans (HR 0.845; 95% CI 0.742-0.962).
“Higher dietary scores (6-10) were associated with reduced risks of composite DMCs (HR 0.845; 95% CI 0.742-0.962)”
Humansin individuals with type 2 diabetes mellitus
GeroScience11 Dec 2025
Latest
6 in 12 monthsDiabetes, Obesity & Metabolism
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GeroScience
Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes
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ADA Scientific Sessions 2025 Abstract
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