Depressive episodes

3 papers2 findings

Humans3

Effects

1

Early-onset dementia

mediatesin humans1

1 study

Depressive episodes mediate early-onset dementia in humans (18.8% (P = 0.014)).
“Incident depressive episode mediated 18.8 % (P = 0.014) and 7.8 % (P < 0.001) of associations between glycemic status with EOD and LOD, respectively.”
Humansin association between glycemic status and EOD
Glycemic status, early-onset and late-onset dementia, dementia-free lifespan, and brain structure: A population-based cohort study
Diabetes research and clinical practice18 Sep 2025

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Associations

1

Alzheimer's disease

upin humans1

1 study

Depressive episodes are associated with Alzheimer's disease in humans.
“In AD, depressive episodes, osteoporosis, and type 1 diabetes appeared up to 20 years pre-diagnosis”
Humansup to 20 years pre-diagnosis
Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank
Alzheimer's & dementia (Amsterdam, Netherlands)10 Feb 2026

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Trial sponsors

Poznan University of Medical Sciences
1 trialPhase 4180 people
The University of Texas Health Science Center at Tyler
1 trialPhase 2200 people
University of Sao Paulo
1 trialPhase 230 people

Latest

13 in 12 months

Journal of the American Heart Association2 Sep

Post-traumatic Psychopathology and Cardiovascular Risk: A Danish Case-Control Study of Sex-Specific Associations

Case-control study in peoplePopulations

medRxiv31 Aug

The timeline of brain aging in major depression: A prospective study from before first-onset to established illness

Preprint: cohort study of 3,220 peopleMajor depressive disorder

Research Square8 Aug

Digital Biomarkers for Healthy Ageing: A Framework for Early Disease Detection Using Language, Typing Behaviour, Smartphone Interactions, and Wearable Sensors A Systematic Scoping Review

Preprint: systematic review of observational studiesBiomarkers

Frontiers in Psychiatry8 Aug

Case Report: Oral semaglutide-associated depression in a patient with type 2 diabetes mellitus: a dose-dependent recurrence confirmed on rechallenge and managed with vortioxetine-bupropion combination therapy

Case reportSemaglutide

Psychiatria Polska30 Apr

Functional Capacity in Older Adults with Depressive Disorders

Cross-sectional study of 71 peopleDepressive disorder

Psychiatry Research25 Apr

Remnant Cholesterol and Incident Depression in Aging: A 14-Year Prospective Cohort Study and Mendelian Randomization Analysis

Cohort study of 4,422 peopleMajor depressive disorder

medRxiv20 Apr

Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortium

Preprint: cross-sectional study of 645 peopleMajor depressive disorder

Journal of Cannabis Research15 Apr

Association between cannabis use and major depressive disorder: a population-based cross-sectional study

Cross-sectional study of 33,749 peopleMajor depressive disorder

BJPsych Open1 Mar

Late-onset depression predicts cognitive impairment and subsequent dementia among older adults with major depressive disorder: findings from UK Biobank and primary care linked data

Cohort study of 75,064 peopleMajor depressive disorder

Aging & Mental Health16 Feb

Depressive symptomology across adult age groups: differences in PHQ-9 symptom endorsement in a US sample

Cross-sectional study of 8,325 peopleDepressive disorder