Late-onset dementia

Disease

2 papers4 findings

  • Humans2

Associations

4

Denture use

upin humans1HR 1.18

1 study
  1. Denture use raises the risk of late-onset dementia in humans (HR 1.18, 95% CI 1.12-1.25).

    “denture use (HR, 1.18; 95% CI, 1.12-1.25)”

    Humanslate-onset dementia13.6 years

    Differential associations of oral health with early- and late-onset dementia: a prospective analysis of the UK Biobank

    The journals of gerontology. Series A, Biological sciences and medical sciences12 Jul 2026

More on Denture use

Toothache

upin humans1HR 1.17

1 study
  1. Toothache raises the risk of late-onset dementia in humans (HR 1.17, 95% CI 1.04-1.33).

    “toothache (HR, 1.17; 95% CI, 1.04-1.33)”

    Humanslate-onset dementia13.6 years

    Differential associations of oral health with early- and late-onset dementia: a prospective analysis of the UK Biobank

    The journals of gerontology. Series A, Biological sciences and medical sciences12 Jul 2026

Painful gums

upin humans1HR 1.24

1 study
  1. Painful gums raise the risk of late-onset dementia in humans (HR 1.24, 95% CI 1.09-1.40).

    “painful gums (hazard ratio [HR], 1.24; 95% CI, 1.09-1.40)”

    Humanslate-onset dementia13.6 years

    Differential associations of oral health with early- and late-onset dementia: a prospective analysis of the UK Biobank

    The journals of gerontology. Series A, Biological sciences and medical sciences12 Jul 2026

Glycemic control

downin humans1−17%

1 study
  1. Glycemic control lowers the risk of late-onset dementia in humans (-17%).

    “and a 17 % lower LOD incidence”

    Humansin diabetes participants

    Glycemic status, early-onset and late-onset dementia, dementia-free lifespan, and brain structure: A population-based cohort study

    Diabetes research and clinical practice18 Sep 2025

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Neurology

Epilepsy linked to dementia diagnosed before age 65

In a French cohort, dementia before 65 developed in 2.20% with newly diagnosed epilepsy versus 0.21% without epilepsy over 10 years.In a French cohort, dementia before 65 developed in 2.20% with newly diagnosed epilepsy versus 0.21% without epilepsy over 10 years.

Cohort study of adults with or without epilepsy, 10 years, against individuals without epilepsyPopulations

Limit: Undiagnosed dementia could precede epilepsy, consistent with weaker associations after delaying follow-up

Frontiers in Aging Neuroscience

Physical activity is linked to lower dementia risk in hypertension

The highest quartile of moderate activity was tied to a hazard ratio of 0.41 compared with the lowest quartile in 47,861 hypertensive adults.The highest quartile of moderate activity was tied to a hazard ratio of 0.41 compared with the lowest quartile in 47,861 hypertensive adults.

Cohort study of 47,861 peopleDementia