Coronary dysfunction

1. UCP2 protects against coronary dysfunction in mice.

   “TRPV1 or UCP2 deficiency exacerbated HFD-induced coronary dysfunction and was associated with increased ROS generation and reduced nitric oxide production in the endothelium.”

   Animalsin HFD-fed ApoE(-/-) mice

   Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1-Mediated Protein Kinase A/Uncoupling Protein 2 Pathway

   Hypertension (Dallas, Tex. : 1979)·14 Dec 2015

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1. TRPV1 protects against coronary dysfunction in mice.

   “TRPV1 or UCP2 deficiency exacerbated HFD-induced coronary dysfunction and was associated with increased ROS generation and reduced nitric oxide production in the endothelium.”

   Animalsin HFD-fed ApoE(-/-) mice

   Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1-Mediated Protein Kinase A/Uncoupling Protein 2 Pathway

   Hypertension (Dallas, Tex. : 1979)·14 Dec 2015

More on TRPV1