Alzheimer's disease-like pathology

1. Anti-follicle-stimulating hormone antibody decreases Alzheimer's disease-like pathology in mice (ovariectomy-provoked).

   “Ovariectomy-provoked AD-like pathologies and cognitive defects in female ApoE4-TR mice are ameliorated by anti-FSH antibody treatment.”

   Animalsovariectomy-provokedfemales

   FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

   Nature communications·Oct 18, 2023

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1. Follicle-stimulating hormone showed no clear effect on Alzheimer's disease-like pathology in ApoE3-TR mice.

   “FSH stimulates AD-like pathologies and cognitive defects in ApoE4-TR mice, but not ApoE3-TR mice.”

   Animalsin ApoE3-TR mice

   FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

   Nature communications·Oct 18, 2023

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1. Alzheimer's disease-like pathology increases cellular senescence in mice (bulk RNA sequencing of Rag-5xFAD brain tissue).

   “Bulk RNA sequencing of Rag-5xFAD brain tissue demonstrated enrichment of disease-associated microglia (DAM) and senescence-related transcriptional programs.”

   Animalsbulk RNA sequencing of Rag-5xFAD brain tissuebrain

   uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology

   Brain research·May 2, 2026

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1. Alzheimer's disease-like pathology increases uPAR expression in mice (5xFAD compared with WT mice).

   “uPAR expression increased with age and was significantly elevated in 5xFAD mice”

   Animals5xFAD compared with WT micebrain

   uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology

   Brain research·May 2, 2026

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1. NLRP3 inflammasome mediates Alzheimer's disease-like pathology in mice (P. gingivalis infection via the microbiota-gut-brain axis).

   “These findings highlight the critical role of NLRP3 inflammasome activation in the microbiota-gut-brain axis in the AD-like pathology induced by P. gingivalis.”

   AnimalsP. gingivalis infection via the microbiota-gut-brain axis24 weeksfemales

   Alzheimer's disease-like pathology induced by Porphyromonas gingivalis in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis

   Journal of Alzheimer's disease : JAD·Dec 5, 2024

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1. Alzheimer's disease-like pathology is associated with respiratory chain complex activities in rats (OXYS rats).

   “low activity of respiratory chain complexes I, IV, and V in cortical mitochondria”

   AnimalsOXYS ratscortical mitochondria

   The Rat Prefrontal-Cortex Transcriptome: Effects of Aging and Sporadic Alzheimer's Disease-Like Pathology

   The journals of gerontology. Series A, Biological sciences and medical sciences·Sep 29, 2018

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1. Alzheimer's disease-like pathology is associated with gene expression in rats (OXYS rats, including the preclinical stage).

   “Gene expression changes during development of AD-like pathology as well as at the preclinical stage were related to neuronal plasticity, catalytic activity, lipid and immune processes, and mitochondria.”

   AnimalsOXYS rats, including the preclinical stageprefrontal cortex

   The Rat Prefrontal-Cortex Transcriptome: Effects of Aging and Sporadic Alzheimer's Disease-Like Pathology

   The journals of gerontology. Series A, Biological sciences and medical sciences·Sep 29, 2018

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