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Weight variability

There are 3 papers on weight variability in aging research: 2 observational studies in people, 1 review. The newest story, Nov 8, 2026: “Weight variability linked to higher death risk in older adults”.

Biomarker

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3 new papers in 30 daysSee all 30 papers on weight variability

“Higher WV was associated with less subsequent weight loss at 6 months (B = -0.38, 95% CI [-0.63, -0.13], β = -0.16, p = 0.003).”
Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE StudyObesity (Silver Spring, Md.)2026doi:10.1002/oby.70235
  • Humans2

Effects

1

Subsequent weight loss

downin humans1

1 study

  1. Weight variability decreases subsequent weight loss in humans (B = -0.38, 95% CI [-0.63, -0.13], β = -0.16, p = 0.003).

    “Higher WV was associated with less subsequent weight loss at 6 months (B = -0.38, 95% CI [-0.63, -0.13], β = -0.16, p = 0.003).”

    Human trial6 monthsn = 143

    Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study

    Obesity (Silver Spring, Md.)

Associations

1

Left ventricular end-diastolic volume index

upin humans1

1 study

  1. Weight variability is associated with left ventricular end-diastolic volume index in humans (Heart failure; weight variability >2.5 kg) (β +4.3 mL/m2, 95% CI +2.1 to +6.5).

    “Weight variability >2.5 kg was associated with blunted remodeling (β +4.3 mL/m 2 , 95% CI +2.1 to +6.5; p=0.002).”

    HumansHeart failure; weight variability >2.5 kgheartMedian 8.2 months54% malesn = 8,000

    Association of Wearable-Derived Physical Activity and Weight Trajectories with Reverse Remodeling on Serial Echocardiography in 8,000 Heart Failure Patients: A Retrospective Multi-Center Cohort Study

    AHA Scientific Sessions 2026 abstract

More on Left ventricular end-diastolic volume index

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Scientific Reports

Weight variability linked to higher death risk in older adults

Comparing the quarters with the most and least variable weight gave a death hazard ratio of 1.62, a relative risk measure adjusted for other factors.Comparing the quarters with the most and least variable weight gave a death hazard ratio of 1.62, a relative risk measure adjusted for other factors.

Cohort · 616,696 peoplePopulations
Paper

See all 30 papers on weight variability

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