Left ventricular end-diastolic volume index

1. Weight variability is associated with left ventricular end-diastolic volume index in humans (Heart failure; weight variability >2.5 kg) (β +4.3 mL/m2, 95% CI +2.1 to +6.5).

   “Weight variability >2.5 kg was associated with blunted remodeling (β +4.3 mL/m 2 , 95% CI +2.1 to +6.5; p=0.002).”

   HumansHeart failure; weight variability >2.5 kgheartMedian 8.2 months54% malesn = 8,000

   Association of Wearable-Derived Physical Activity and Weight Trajectories with Reverse Remodeling on Serial Echocardiography in 8,000 Heart Failure Patients: A Retrospective Multi-Center Cohort Study

   AHA Scientific Sessions 2026 abstract·Nov 2, 2026

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1. Daily steps are associated with left ventricular end-diastolic volume index in humans (Heart failure; adjusted for GDMT and comorbidities) (β -2.1 mL/m2 per 1,000 daily steps above median, 95% CI -2.7 to -1.5).

   “Each 1,000 daily steps above median was independently associated with a 2.1 mL/m 2 greater reduction in LVEDVi”

   HumansHeart failure; adjusted for GDMT and comorbiditiesheartEach 1,000 daily steps above medianMedian 8.2 months54% malesn = 8,000

   Association of Wearable-Derived Physical Activity and Weight Trajectories with Reverse Remodeling on Serial Echocardiography in 8,000 Heart Failure Patients: A Retrospective Multi-Center Cohort Study

   AHA Scientific Sessions 2026 abstract·Nov 2, 2026

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1. age is associated with left ventricular end-diastolic volume index in humans (healthy adults) (R=-0.348, p=0.001).

   “Significant correlations were found between age and LVEDVi (R=-0.348 p=0.001), LVESVi (R=-0.298, p=0.006) and LVMi (R=-0.350, p=0.003).”

   Humanshealthy adultsheartn = 104

   Age and sex specific normal reference values for 3T spin echo cardiac diffusion tensor imaging in 104 healthy subjects

   ESC Congress 2026 abstract·Oct 26, 2026

1. Physical frailty is associated with left ventricular end-diastolic volume index in humans (sex interaction showing steeper decline in men) (interaction β = -1.455).

   “significant interactions were observed for left ventricular mass index (β=−1.474, p = 0.002) and left ventricular end-diastolic volume index (β=−1.455, p < 0.001), indicating steeper declines in men compared with women”

   Humanssex interaction showing steeper decline in menheartmalesn = 48,993

   Sex-specific associations of physical frailty with cardiac structure and function: a cross-sectional study based on UK Biobank

   BMC cardiovascular disorders·Apr 9, 2026

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1. eGFR is associated with left ventricular end-diastolic volume index in humans.

   “Lower eGFR was associated with larger increases in left ventricular end-diastolic volume index and worsening of diastolic measures.”

   Humansn = 2,313

   Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study

   JACC. Heart failure·Apr 12, 2023

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