Papers on type I interferon

168 papers7 new in 30 days

Sunday, March 31

Nature CommunicationsMar 31

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Experiments in cellsSenescence-associated secretory phenotype (SASP)

Paper

Tuesday, March 12

bioRxivMar 12

cGAS-STING is responsible for aging of telomerase deficient zebrafish

Preprint: experiments in zebrafishcGAS–STING signaling

Paper

Monday, February 26

Nature CommunicationsFeb 26

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Experiments in miceType I interferon signaling

Paper

Thursday, February 8

bioRxivFeb 8

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Preprint: experiments in miceCellular senescence

Paper

Saturday, January 27

Nature CommunicationsJan 27

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Experiments in miceInterventions

Paper

Thursday, January 11

NatureJan 11

Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage

Experiments in miceMechanisms

Paper

Thursday, November 30

Frontiers in Molecular NeuroscienceNov 30

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes

Experiments in cellsMechanisms

Paper

Thursday, November 9

Molecular NeurodegenerationNov 9

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

ReviewType I interferon signaling

Paper

Wednesday, October 18

Alzheimer's & DementiaOct 18

The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology

Experiments in animalsMechanisms

Paper

Wednesday, July 5

Research SquareJul 5

Age-Related Impairment of Innate and Adaptive Immune Responses Exacerbate Respiratory Viral Infection in Older Mice

Preprint: experiments in miceImmune response

Paper

Monday, June 19

medRxivJun 19

Social genomics, cognition, and well-being during the COVID-19 pandemic

Preprint: cross-sectional study of 143 peoplePopulations

Paper

Saturday, May 27

Cell ReportsMay 27

Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions

Experiments in miceDietary restriction

Paper

Thursday, April 13

Seminars in ImmunopathologyApr 13

Differences in the post-stroke innate immune response between young and old

ReviewImmune response

Paper

Thursday, March 30

bioRxivMar 30

Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases

Preprint: experiments in human cellsCellular senescence

Paper

Saturday, March 11

EMBO Molecular MedicineMar 11

Nerve regeneration by interferon intervention in aging brain

CommentaryType I interferon signaling

Paper

Friday, March 3

MedicineMar 3

Identification microenvironment immune features and key genes in elderly stroke patients

Computational studyImmune response

Paper

Thursday, February 23

Communications BiologyFeb 23

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Experiments in human cellsMechanisms

Paper

Tuesday, January 3

eLifeJan 3

The meningeal transcriptional response to traumatic brain injury and aging

Experiments in miceImmune response

Paper

Tuesday, December 27

GliaDec 27

Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model

Experiments in human cellsDNA damage response

Paper

Friday, November 18

Immunity & AgeingNov 18

The oldest unvaccinated Covid-19 survivors in South America

Case series of 3 peopleMechanisms

Paper

Saturday, October 22

Ageing Research ReviewsOct 22

Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks

ReviewMechanisms

Paper

Wednesday, October 19

The Journal of NeuroscienceOct 19

Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain following Diffuse Traumatic Brain Injury

Experiments in miceType I interferon signaling

Paper

Sunday, October 2

Scientific ReportsOct 2

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease

Experiments in miceType I interferon signaling

Paper

Thursday, August 11

Cell CycleAug 11

The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors

ReviewType I interferon signaling

Paper

Tuesday, July 26

Nature ImmunologyJul 26

IRF3 and IRF7 require SIRT1 for liquid-liquid phase separation and transactivation of IFN-1

ReviewSirtuin signaling

Paper

Saturday, July 23

CytokineJul 23

Distinct type I interferon responses between younger women and older men contribute to the variability of COVID-19 outcomes: Hypothesis generating insights from COVID-19 convalescent individuals

Cohort study of 61 peopleType I interferon signaling

Paper

Tuesday, July 19

GeroScienceJul 19

Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists

Experiments in human cellsType I interferon signaling

Paper

Saturday, July 9

Cell Stem CellJul 9

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease

Experiments in miceType I interferon signaling

Paper

Friday, July 1

Frontiers in ImmunologyJul 1

The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration

Experiments in micecGAS–STING signaling

Paper

Monday, May 23

bioRxivMay 23

Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence

Preprint: experiments in human cellsDNA damage response

Paper