Free Radical Biology & Medicine
Gene variant linked to greater brain inflammation in aging mice
Experiments in mice aged 4, 12 and 20 months linked a human gene variant to greater buildup of sugar-modified molecules and inflammatory signaling.Experiments in mice aged 4, 12 and 20 months linked a human gene variant to greater buildup of sugar-modified molecules and inflammatory signaling.
Mouse studyInflammation
Who was studiedHumanized apolipoprotein E targeted replacement mice, against APOE3 controls
What changedAged APOE4 mice had higher cortical levels of inflammatory cytokines and interferon than APOE3 controls
The catchInterferon bioactivity, neuronal viability, and cognitive function were not measured