Total nicotine equivalents

1. Total nicotine equivalents are associated with DunedinPACE in humans (β = 0.015, 95% CI 0.010–0.020 per SD increase in log-TNE).

   “DunedinPACE (beta = 0.015, 95%CI=0.010-0.020)”

   HumansCurrent cigarette smokers; adjusted for self-reported pack-years and other covariatesPer SD increase in log-TNEn = 1,969

   The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study

   Clinical epigenetics·22 Apr 2026

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1. Total nicotine equivalents are associated with AgeAccelGrim in humans (β = 0.771, 95% CI 0.603–0.939 per SD increase in log-TNE).

   “AgeAccelGrim (beta = 0.771, 95%CI=0.603-0.939)”

   HumansCurrent cigarette smokers; adjusted for self-reported pack-years and other covariatesPer SD increase in log-TNEn = 1,969

   The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study

   Clinical epigenetics·22 Apr 2026

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1. Total nicotine equivalents are associated with AgeAccelPheno in humans (β = 0.416, 95% CI 0.134–0.698 per SD increase in log-TNE).

   “A standard deviation (SD) increase of log-TNE was statistically significantly associated with increased AgeAccelPheno (beta = 0.416, 95% Confidence Interval (CI)=0.134-0.698))”

   HumansCurrent cigarette smokers; adjusted for self-reported pack-years and other covariatesPer SD increase in log-TNEn = 1,969

   The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study

   Clinical epigenetics·22 Apr 2026

More on AgeAccelPheno