AgeAccelDNAm-based telomere length

1. AgeAccelDNAm-based telomere length is associated with lung cancer in humans (HR 0.79, 95% CI 0.67–0.93).

   “a SD increase of AgeAccelDNAm-based telomere length was inversely associated with lung cancer risk (HR = 0.79; 95% CI 0.67-0.93)”

   HumansCurrent cigarette smokers; adjusted for pack-years, urinary TNE, and other covariatesPer SD increase in AgeAccelDNAm-based telomere length13 yearsn = 1,969

   The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study

   Clinical epigenetics·22 Apr 2026

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