Telomere-associated foci

3 papers1 finding

Animals3

Upstream

1

HDAC3

downin mouse cells1

1 study

HDAC3 decreases telomere-associated foci in mouse cells.
“Runx2+ BMSCs from Hdac3 CKOOsx mice also contained more SADS and TAFs per nuclei than Runx2+ cells from age-matched control mice in vitro.”
Cellsshown by conditional Hdac3 deletion compared with age-matched controlsRunx2-positive bone marrow stromal cells
Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchJun 6, 2024

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