Telomere-associated DNA damage

There are 3 papers on telomere-associated DNA damage in aging research: none in people yet, 3 in animals.

3 papers study it8 more mention it2 findings

1 new paper in 30 daysSee all 11

Animals3

Interventions

2

Compound 78c

downin mice1

1 study

Compound 78c decreases telomere-associated DNA damage in treated animals.
“attenuation of telomere-associated DNA damage, a marker of cellular aging”
Animalsin treated animals
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD⁺ Decline
Cell metabolismMay 1, 2018

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TRF1 gene therapy

downin mice1

1 study

TRF1 gene therapy decreases telomere-associated DNA damage in mice.
“we found a lower abundance of short telomeres and of telomere-associated DNA damage in some tissues”
Animalssome tissues
Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
Aging cellSep 24, 2017

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Latest

4 papers in 12 months

Cell MetabolismMay 1

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD⁺ Decline

Experiments in miceMetabolic dysfunction

Environmental PollutionFeb 21

TERT regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to BPDE in vitro and to B[a]P in vivo

Experiments in ratsTelomerase and telomere maintenance

Aging CellSep 26

Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span

Experiments in miceInterventions

Regenerative TherapyOct 6

Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies

ReviewCellular senescence

Laboratory Investigation; a Journal of Technical Methods and PathologyMay 31

Telomere Shortening and p16-Associated Senescence in Myofibromas

Cross-sectional study of 33 peopleTelomerase and telomere maintenance

EMBO Molecular MedicineApr 2

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

Experiments in miceInterventions

iScienceMar 12

Replicative senescence induction in single cells is not predicted by telomere length, dysfunction, or oxidation

Experiments in human cellsTelomerase and telomere maintenance

Aging CellJul 17

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Experiments in miceTelomerase and telomere maintenance

GeroScienceJul 12

Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study

Cross-sectional study in peopleCellular senescence

GenesApr 28

Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity

Experiments in cellsTelomerase and telomere maintenance