TRF1 gene therapy
TRF1 gene therapy has been studied in 1 paper since 2017: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Sep 24, 2017: “Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span”.
1 paper studies it6 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Catalan Institution for Research and Advanced Studies and 1 more
- Animals1
What did studies of TRF1 gene therapy find?
6Studies of TRF1 gene therapy measured 6 outcomes; the most studied are telomere-associated DNA damage (1 study), median telomere length (1) and chronic anemia (1).
Telomere-associated DNA damage
downin mice1
1 study
Telomere-associated DNA damage
downin mice1
TRF1 gene therapy decreases telomere-associated DNA damage in mice.
“we found a lower abundance of short telomeres and of telomere-associated DNA damage in some tissues”
Animalssome tissues
Aging cell
Median telomere length
no changein mice1
1 study
Median telomere length
no changein mice1
TRF1 gene therapy showed no clear effect on median telomere length in mice.
“although AAV9-TRF1 treatment did not significantly affect median telomere length”
Animals
Aging cell
Chronic anemia
downin mice1
1 study
Chronic anemia
downin mice1
TRF1 gene therapy prevents chronic anemia in mice.
“AAV9-TRF1 gene therapy significantly prevented age-related decline in neuromuscular function, glucose tolerance, cognitive function, maintenance of subcutaneous fat, and chronic anemia”
Animalsnonintegrative adeno-associated serotype 9 vector
Aging cell
Glucose tolerance
upin mice1
1 study
Glucose tolerance
upin mice1
TRF1 gene therapy improves glucose tolerance in mice.
“AAV9-TRF1 gene therapy significantly prevented age-related decline in neuromuscular function, glucose tolerance, cognitive function, maintenance of subcutaneous fat, and chronic anemia”
Animalsnonintegrative adeno-associated serotype 9 vector
Aging cell
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
TRF1 gene therapy improves cognitive function in mice.
“AAV9-TRF1 gene therapy significantly prevented age-related decline in neuromuscular function, glucose tolerance, cognitive function, maintenance of subcutaneous fat, and chronic anemia”
Animalsnonintegrative adeno-associated serotype 9 vector
Aging cell
Neuromuscular function
upin mice1
1 study
Neuromuscular function
upin mice1
TRF1 gene therapy improves neuromuscular function in mice.
“AAV9-TRF1 gene therapy significantly prevented age-related decline in neuromuscular function, glucose tolerance, cognitive function, maintenance of subcutaneous fat, and chronic anemia”
Animalsnonintegrative adeno-associated serotype 9 vector
Aging cell