Synovitis index

1. Synovium-targeting liposomes delivering senolytics + M2 macrophage-derived exosomes decrease synovitis index in rats (-73.53%).

   “achieving 73.53% synovitis index reduction and 75.00% OARSI score reduction”

   Animalsin rat OA models

   Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis

   ACS nano·4 Feb 2026

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