OARSI score

5 papers2 findings

Animals5

Interventions

2

HM17321

downin mice1

1 study

HM17321 decreases OARSI score in mice (7.3 vs. 9.6 vehicle).
“OARSI score for joint cartilage was lowered by HM17321 (7.3 vs. 9.6, vehicle; 0.6, Sham vehicle).”
Animalsin HFD/DMM micecartilage100 nmol/kg6 weeks
Protective Effects of HM17321, a Novel UCN2 Analog, on Obesity-Associated Musculoskeletal Diseases in Mouse Models
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on HM17321

Synovium-targeting liposomes delivering senolytics + M2 macrophage-derived exosomes

downin rats1−75%

1 study

Synovium-targeting liposomes delivering senolytics + M2 macrophage-derived exosomes decrease OARSI score in rats (-75.00%).
“achieving 73.53% synovitis index reduction and 75.00% OARSI score reduction”
Animalsin rat OA models
Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis
ACS nano4 Feb 2026

More on Synovium-targeting liposomes delivering senolytics + M2 macrophage-derived exosomes

Latest

7 in 12 months

Osteoarthritis and Cartilage8 Aug

TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway

Experiments in micePI3K–AKT signalling

ADA Scientific Sessions 2026 Abstract5 Jun

Protective Effects of HM17321, a Novel UCN2 Analog, on Obesity-Associated Musculoskeletal Diseases in Mouse Models

Experiments in miceMusculoskeletal disease

Phytomedicine1 Mar

Pyrroloquinoline quinone alleviates age-related osteoarthritis via nuclear factor erythroid 2-related factor 2-mediated stress response and insulin-like growth factor 1 receptor upregulation

Experiments in miceKnee osteoarthritis

ACS Nano4 Feb

Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis

Experiments in ratsBones and joints

Cell Biology and Toxicology1 Feb

Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence

Experiments in miceCellular senescence

bioRxiv16 Jan

3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee Joints

Preprint: experiments in 38 miceBones and joints

Journal of Inflammation Research10 Nov

Retinoic Acid-Loaded Cartilage Organoids Attenuate Chondrocyte Senescence in Osteoarthritis

Experiments in ratsOsteoarthritis