Synapse-pruning and microglial signatures

longer-lifespan-associated genetic variants are associated with synapse-pruning and microglial signatures in humans.

“synapse-pruning and microglial signatures were upregulated”

Humanstranscriptome-wide association analysis of longer lifespan

Tissue-Resolved Transcriptome-Wide Association Study Reveals Targeted NAD⁺ Salvage, Synaptic Refinement, and Reduced Insulin Drive as Transcriptional Mechanisms of Human Lifespan

Figshare·7 Apr 2026Preprint